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KMID : 0043320040270020156
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Archives of Pharmacal Research
2004 Volume.27 No. 2 p.156 ~ p.163
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Synthesis and Antioxidant Properties of Some Novel Benzimidazole Derivatives on Lipid Peroxidation in the Rat Liver
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Canan Kus
Gulguin Ayhan-Kilcigil
Benay Can Eke
Mumtaz iucan
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Abstract
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Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a),N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-ylj-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and theirin vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound10a caused an 84% inhibition of LP at 10-3 M, which is better than that of butylated hydroxytoluene (BHT) (65%).
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KEYWORD
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Thiosemicarbazides, Thiadiazolylmethylbenzimidazoles, Triazolylbenzimidazoles, Antioxidant
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